Sunday, April 12, 2009

Formation and hydrolysis of cAMP

The key reaction is the formation of cyclic adenosine
monophosphate (cAMP) fromadenosine
triphosphate (ATP) by means of adenylate cyclase.
Intracellular cyclic AMP transmits the activation
initiated by the hormone–receptor
complex without a molecule having passed
through the plasma membrane. cAMP is responsible
for many physiological reactions. It
becomes inactivated when converted into adenosine
monophosphate (AMP) by phosphodiesterase.
cGMP (cyclic guanosine monophosphate)
functions in the same manner as
cAMP to initiate an intracellular reaction.

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